Public Class Form1
[..]
    Private Sub Form1_KeyDown(ByVal sender As Object, ByVal e As _
      System.Windows.Forms.KeyEventArgs) Handles Me.KeyDown
        If ((e.Modifiers = Keys.Control) AndAlso (e.KeyCode = Keys.C)) Then
            MessageBox.Show("CTRL+C pressed")
        End If
    End Sub
 
    Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As _
      System.EventArgs) Handles MyBase.Load
        Me.KeyPreview = True
    End Sub