Public Class Form1
    Private WithEvents t As New Timer
 
    Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As _
      System.EventArgs) Handles MyBase.Load
        PictureBox1.SetBounds(10, 10, 20, 20)
        t.Start()
    End Sub
 
    Private Sub t_Tick(ByVal sender As Object, ByVal e As System.EventArgs) _
      Handles t.Tick
        Using bm As Bitmap = New Bitmap(1, 1), g As Graphics = _
        Graphics.FromImage(bm)
            g.CopyFromScreen(Windows.Forms.Cursor.Position.X, _
            Windows.Forms.Cursor.Position.Y, 0, 0, bm.Size)
            PictureBox1.BackColor = bm.GetPixel(0, 0)
        End Using
    End Sub
End Class