Try
            Dim bmp As New Bitmap(PictureBox1.Width, PictureBox1.Height)
            Using g As Graphics = Graphics.FromImage(bmp)
                Dim pt As Point = PictureBox1.PointToScreen(New Point(0, 0))
                g.CopyFromScreen(pt.X, pt.Y, 0, 0, bmp.Size)
            End Using
            PictureBox1.Image = bmp
            PictureBox1.Image.Save("C:\users\frank\desktop\1.bmp")
        Catch
        End Try